Observation of cardiac lipids in humans by localized 1H magnetic resonance spectroscopic imaging

✍ Scribed by Jan A. den Hollander; William T. Evanochko; Gerald M. Pohost

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 609 KB
• Volume: 32
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910320205

✦ Synopsis

Abstract

Different approaches are being explored for the noninvasive observation of myocardial lipids in the human heart by in vivo ^1^H NMR spectroscopy. One approach is to measure cardiac lipids using a combination of volume selection and 2D gradient phase encoding. From these data sets lipid images can be reconstructed. By comparing these lipid images with ^1^H MR scout images, it is demonstrated that these signals represent epicardial and pericardial lipid. By selecting a smaller bar‐shaped volume combined with 1D phase encoding or by using single volume techniques, it is possible to avoid most of the pericardial and epicardial lipid to obtain myocardial ^1^H NMR spectra of the human heart showing lipid signals, as well as trimethylamine and (phospho)creatine signals. These measurements demonstrate the feasibility of obtaining ^1^H NMR spectra of the human myocardium.