Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging
✍ Scribed by Dr James W. Hugg; Ruben I. Kuzniecky; Frank G. Gilliam; R. Edward Faught; Richard B. Morawetz; Hoby P. Hetherington
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 415 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0364-5134
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✦ Synopsis
We studied 10 medically intractable temporal lobe epilepsy (TLE) patients prior to surgery using proton magnetic resonance spectroscopic imaging (MRSI) to localize seizure foci. We found significantly elevated creatine/ Nacetylaspartate (CrlNAA) unilaterally in 8 and bilaterally in 2 patients. Five patients have been studied again 1 year after surgery. In the 2 patients with bilateral temporal seizure onsets, MRSI showed normalization of Cr/NAA in the unoperated contralateral tissue following surgical elimination of seizures. This study suggests that metabolic recovery can occur in contralateral temporal areas following surgical treatment of partial epilepsy. Hugg JW, Kuzniecky RI, Gilliam FG, Morawetz RB, Faught RE, Hetherington H I ' . Normalization of contralateral metabolic function following temporal lobectomy demonstrated by ' H magnetic resonance spectroscopic imaging.