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Quantification of dextromethorphan and metabolites: a dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity

✍ Scribed by David R. Jones; J.Chris Gorski; Mitchell A. Hamman; Stephen D. Hall

Publisher
Elsevier Science
Year
1996
Weight
505 KB
Volume
678
Category
Article
ISSN
0378-4347

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Metabolism of Dextromethorphan in vitro:
Metabolism of Dextromethorphan in vitro: Involvement of Cytochromes P450 2D6 AND 3A3/4, with a Possible Role of 2E1
✍ JÜRGEN SCHMIDER; DAVID J. GREENBLATT; STEVEN M. FOGELMAN; LISA L. VON MOLTKE; RI πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 191 KB πŸ‘ 1 views

Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab