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Comparative cytochrome P450 -1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level

✍ Scribed by Devrim Sarikaya; Cem Bilgen; Tetsuya Kamataki; Zeki Topcu


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
122 KB
Volume
27
Category
Article
ISSN
0142-2782

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Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab