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Quantification of cibenzoline and its imidazole metabolite by high-performance liquid chromatography in human serum

✍ Scribed by V. Kühlkamp; F. Schmid; K.M. Ress; B.K. Krämer; F. Mayer; H.M. Liebich; T. Risler; L. Seipel


Book ID
108448314
Publisher
Elsevier Science
Year
1990
Weight
412 KB
Volume
528
Category
Article
ISSN
0378-4347

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The antihypertensive agent urapidil (Ebrantil Byk-Gulden, Konstanz) can be reliably quantitated with three metabolites in human serum using high performance liquid chromatography. Serum is alkalinized and extracted with ethyl acetate. The organic phase is back-extracted with diluted acid. An aliquot