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Quantification of aristolochic acid-derived DNA adducts in rat kidney and liver by using liquid chromatography–electrospray ionization mass spectrometry

✍ Scribed by Wan Chan; Hao Yue; Wing Tat Poon; Yan-Wo Chan; Oliver J. Schmitz; Daniel W.J. Kwong; Ricky N.S. Wong; Zongwei Cai

Book ID: 113809211
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 674 KB
Volume: 646
Category: Article
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2008.08.012

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## Abstract High‐performance liquid chromatography (HPLC) was combined with electrospray ionization tandem mass spectrometry (ESI‐MS/MS) to develop a sensitive and selective method for the quantitative measurement of __N__^7^‐(2‐hydroxyethyl)guanine (__N__^7^‐HEG) adducts in DNA obtained from ethyl