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Qualitative assessment of leachables using data-dependent liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry

✍ Scribed by P. R. Tiller; Z. El Fallah; V. Wilson; J. Huysman; D. Patel

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
134 KB
Volume
11
Category
Article
ISSN
0951-4198

No coin nor oath required. For personal study only.

✦ Synopsis

Data-dependent liquid chromatography tandem mass spectrometry was utilized to identify leachables from adhesives used in pharmaceutical products. This approach affords a significant increase in the amount of data obtained from a single experiment. No information about the sample is needed a priori to perform these analyses. The data thus acquired speeded up the selection of the appropriate adhesive and shortened the development time of the drug product.

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