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Liquid Chromatography/Electrospray Tandem Mass Spectrometry of Methylated Purine Bases

✍ Scribed by Silvia Catinella; Luca Rovatti; Mahmoud Hamdan; Brunetta Porcelli; Barbara Frosi; Enrico Marinello

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 187 KB
Volume: 11
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(199705)11:8<869::aid-rcm923>3.0.co;2-d

No coin nor oath required. For personal study only.

✦ Synopsis

Aqueous solutions containing synthetic mixtures of model methylated purine bases have been examined by liquid chromatography/electrospray tandem mass spectrometry. Efficient chromatographic separation together with characteristic fragment ions derived from selected parent molecular ions allowed fast and reliable identification of the individual components within the investigated mixtures including some isomeric structures. Some of the deductions in the present work regarding the chromatography and mass spectrometry can be easily extended to analysis which may involve biofluids containing members of this class of compounds.

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