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QS96. Aging Effects on The Von Hippel Lindau (VHL) Tumor Suppressor Pathway in The Development of Renal Carcinoma

✍ Scribed by Edward M. Uchio; Rohit Garg; Yan Li; Charles Cha; John Schmitz; Jonathan Hwang


Book ID
116703868
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
186 KB
Volume
144
Category
Article
ISSN
0022-4804

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Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1