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Pyruvate kinase type M2 and its role in tumor growth and spreading

✍ Scribed by Sybille Mazurek; C. Bruce Boschek; Ferdinand Hugo; Erich Eigenbrodt


Book ID
113900212
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
218 KB
Volume
15
Category
Article
ISSN
1044-579X

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## Abstract Proliferating cells express the pyruvate kinase isoenzyme type M2 (M2‐PK). This enzyme exists as an active tetramer and an inactive dimer. The dimeric form is predominantly found in tumor cells and is therefore termed Tumor M2‐PK (TuM2‐PK). TuM2‐PK molecules are released into the periph

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