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Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2)

✍ Scribed by Anderson, David R.; Meyers, Marvin J.; Vernier, William F.; Mahoney, Matthew W.; Kurumbail, Ravi G.; Caspers, Nicole; Poda, Gennadiy I.; Schindler, John F.; Reitz, David B.; Mourey, Robert J.


Book ID
120285015
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
352 KB
Volume
50
Category
Article
ISSN
0022-2623

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A class of inhibitors of mitogen activated protein kinase-activated kinase 2 (MK2) was discovered via high-throughput screening. This compound class demonstrates activity against the enzyme with sub-microM IC(50) values, and suppresses LPS-induced TNFalpha levels in THP-1 cells. MK2 inhibition kinet