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Pyrrolizidine alkaloid-induced alterations in benzo[a]pyrene metabolism and binding of benzo[a]pyrene metabolites to deoxyribonucleic acid

✍ Scribed by David E. Williams; Cristobal L. Miranda; Donald R. Buhler


Book ID
115777309
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
455 KB
Volume
32
Category
Article
ISSN
0006-2952

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## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8‐dihydro‐7,8‐dihydroxy