Pyrimidines. IX. 4- and 5-(Substituted-anilino)pyrimidines
✍ Scribed by O'Brien, Darrell E.; Baiocchi, Fred.; Robins, Roland K.; Cheng, C. C.
- Book ID
- 120986384
- Publisher
- American Chemical Society
- Year
- 1962
- Tongue
- English
- Weight
- 970 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0022-2623
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4-Aryl-2-anilinopyrimidines and 2,4-dianilinopyrimidines are privileged structures found in many druglike molecules and biologically active compounds. A method for the quick assembly of novel 4-aryl-and 4-anilino-2-(heteroarylamino)pyrimidines via Buchwald-Hartwig N-arylations at elevated temperatur
The synthesis and physiological activity of some novel 4-substituted triazolo [4,5-d]pyrimidines and 4-substituted pyrazolo [3,4-d]pyrimidines are described. Most of the compounds possessed high anticytokinin activity towards purine (benzyladenine) and phenylurea (4-PU-30) type cytokinins. 1-Benzyl-
## Abstract It is demonstrated that non‐nucleophilic heteroarylamines undergo Buchwald—Hartwig N‐arylation with 4‐substituted 2‐chloropyrimidines to afford drug‐like derivatives including analogues (VIc,d) of the reverse transcriptase inhibitor dapivirine.