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ChemInform Abstract: Convenient Preparation of 4-Aryl-2-(heteroarylamino)pyrimidines and 4-Anilino-2-(heteroarylamino)pyrimidines.

✍ Scribed by Brian I. Bliss; Feryan Ahmed; Subashree Iyer; Weimin Lin; Joel Walker; He Zhao

Book ID
102056318
Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

It is demonstrated that non‐nucleophilic heteroarylamines undergo Buchwald—Hartwig N‐arylation with 4‐substituted 2‐chloropyrimidines to afford drug‐like derivatives including analogues (VIc,d) of the reverse transcriptase inhibitor dapivirine.

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