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Pyridoxal-mediated cycloaromatization of an enediyne model system

✍ Scribed by Masakazu Wakayama; Hisao Nemoto; Masayuki Shibuya


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
217 KB
Volume
37
Category
Article
ISSN
0040-4039

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Synthesis of the sulfone containing lo-membered enediyne derivative 3 and its cycloaromatization in basic conditions via an ailenic sulfone intermediate as well as its DNA cleaving activities are described. The new class of antitumor antibiotics calicheamicins,l esperamicins,\* and dynemicin As hav