✦ LIBER ✦
Cycloaromatization of a 10-membered enediyne derivative via an allenic sulfone intermediate and its DNA cleaving activity
✍ Scribed by Yasuhiro Sakai; Yuri Bando; Kozo Shishido; Masayuki Shibuya
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 272 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Synthesis of the sulfone containing lo-membered enediyne derivative 3 and its cycloaromatization in basic conditions via an ailenic sulfone intermediate as well as its DNA cleaving activities are described.
The new class of antitumor antibiotics calicheamicins,l esperamicins,* and dynemicin As have attracted considerable attention due to their very high biological activity as well as their potent DNAcleaving activities.