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Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication

✍ Scribed by Shuang Wei; Florentina Marches; Ben Daniel; Sabrina Sonda; Kim Heidenreich; Tyler Curiel


Book ID
114043360
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
361 KB
Volume
32
Category
Article
ISSN
0020-7519

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Mammalian mitogen-activated protein kinases include the extracellular signal-regulated protein kinase, the c-Jun amino-terminal kinase, and the p38 subgroups. Sustained activation of Jun kinase and p38 have been shown to precede apoptosis of PC12 pheochromocytoma cells induced by withdrawal of troph