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Pyridine nucleotide metabolism in imaginal discs ofDrosophila melanogaster

✍ Scribed by Ted W. Keyes; Baldomero M. Olivera; D. J. Stewart; E. W. Hanly

Book ID: 104784240
Publisher: Springer
Year: 1976
Tongue: English
Weight: 510 KB
Volume: 14
Category: Article
ISSN: 0006-2928
DOI: 10.1007/bf00484760

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✦ Synopsis

The pyridine nucleotide metabolism of imaginal discs of Drosophila melanogaster has been studied in vitro by incubating discs with labeled nicotinic acid in the presence and absence of ecdysterone. The major labeled compounds found within the discs are NAD, NADP, and nicotinic acid. There is preferential uptake of nicotinamide over nicotinic acid, although the Priess-Handler pathway is used exclusively. The presence of ecdysterone produces a small increase in the NADP/NAD ratio, and an increase in NAD synthesis, probably to compensate for increased NAD turnover.

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