Pyridazines VIII. Some 6-aryl-3-(basically-substituted) pyridazines
✍ Scribed by Edgar A. Steck; R. Pauline Brundage; Lynn T. Fletcher
- Book ID
- 112123568
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1975
- Tongue
- English
- Weight
- 290 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0022-152X
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## Abstract Some novel 3‐halo‐6‐(4‐substituted‐phenoxy)pyridazines and 3,6‐di‐(4‐substituted‐phenoxy)pyridazines were synthesized from 3,6‐dichloropyridazine or 3,6‐diiodopyridazine. 3,6‐Diiodopyridazine was prepared from 3,6‐dichloropyridazine using hydriodic acid/iodine monochloride.
Stamng from 3,6&chloropyndazme, a senes of new pyndazines beanng htlnauonduectmg groups in a-posmon to a nng mtrogen atom (compounds 1-5) was prepared Metalahon employmg hthmm alkylanudes was found to afford or&o-subsututed pyndazmes The reposelectivity, dependmg on the nature of the metalatmg agent