Pyridazine Derivatives, VIII1): Synthesis and Antihypertensive Activity of 6-(2-Thienyl)-5-aminomethyl-3-hydrazino-pyridazines
β Scribed by Enrique Ravina; Carmen Teran; Neftali G. Dominguez; Christian F. Masaguer; Jose Gil-Longo; Francisco Orallo; Jose M. Calleja
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 380 KB
- Volume
- 324
- Category
- Article
- ISSN
- 0365-6233
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The novel and versatile cyanomethyl 2amino-4-methylthiazolyl ketone (5) was prepared by treatment of bromomethyl 2-amino-4-methyl thiazolyl ketone (4) with potassium cyanide. Reaction of 5 with heterocyclic diazonium salts 6a,b and 10 afforded the corresponding hydrazones 7a,b and 11, respectively.