✦ LIBER ✦

Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-c]pyridazine and its hydrazone derivatives

✍ Scribed by Jose Gil-Longo; Maria De Los Reyes Laguna; Ignacio Verde; Maria Elena Castro; Francisco Orallo; Jose Angel Fontenla; Jose Maria Calleja; Enrique Ravina; Carmen Teran

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 571 KB
Volume: 82
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600820314

No coin nor oath required. For personal study only.

✦ Synopsis

0 3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N'-(isopropylidene]] hydrazinocyclohexyl[ 1,2- clpyridazine (5) and 3-[A"-(isobutylidene)]hydrazinocycloheptyl[1,2dpyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCIinduced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.

📜 SIMILAR VOLUMES

Pyridazine Derivatives, VIII1): Synthesi

Pyridazine Derivatives, VIII1): Synthesis and Antihypertensive Activity of 6-(2-Thienyl)-5-aminomethyl-3-hydrazino-pyridazines

✍ Enrique Ravina; Carmen Teran; Neftali G. Dominguez; Christian F. Masaguer; Jose 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 380 KB 👁 2 views

Pyridazine Derivatives, VII. Synthesis a

Pyridazine Derivatives, VII. Synthesis and Hypotensive Activity of 3-Hydrazinocycloalkyl[1,2-c]pyridazines and their Derivatives

✍ Carmen Terán; Enrique Raviña; Lourdes Santana; Neftalí García-Domínguez; Gerardo 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB 👁 2 views

One pot syntheses of thiazol-2-hydrazone

One pot syntheses of thiazol-2-hydrazone, pyridino[2,3-d]pyridazine, pyrazolo[3,4-d]pyridazine, and isoxazolo[4,5-d]pyridazine derivatives

✍ Rafat M. Mohareb; Daisy H. Fleita 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 1 views

## Abstract Reactions of the pyridazine derivatives **1a–c** with phenyl isothiocyanate followed by heterocyclization with ethyl chloroacetate gave the thiazolidinone derivatives **6a–c**. The reactivity of **6a** towards some chemical reagents was studied. © 2002 Wiley Periodicals, Inc. Heteroatom

Pyridazine Derivatives, VI. Synthesis an

Pyridazine Derivatives, VI. Synthesis and Hypotensive Activity of 3-Hydrazinethieno(2,3-h)Cinnoline and its Derivatives

✍ Neftali Garcia-Dominguez; Enrique Raviña; Lourdes Santana; Carmen Terán; Gerardo 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 346 KB 👁 2 views

ChemInform Abstract: One-Pot Syntheses o

ChemInform Abstract: One-Pot Syntheses of Thiazol-2-hydrazone, Pyridino[2,3-d]pyridazine, Pyrazolo[3,4-d]pyridazine, and Isoxazolo[4,5-d]pyridazine Derivatives.

✍ Rafat M. Mohareb; Daisy H. Fleita 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Synthesis and Antihypertensive Propertie

Synthesis and Antihypertensive Properties of Some Dopamino-pyridazin-3(2H)-one Derivatives

✍ Stefano Corsano; Giovannella Strappaghetti; Rossana Scapicchi; Vittorio Anania 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 406 KB 👁 2 views