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Purine mutants of mammalian cell lines. I. Accumulation of formylglycinamide ribotide by purine mutants of Chinese hamster ovary cells

โœ Scribed by Rhoda I. Feldman; Milton W. Taylor

Book ID
104785540
Publisher
Springer
Year
1974
Tongue
English
Weight
604 KB
Volume
12
Category
Article
ISSN
0006-2928

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๐Ÿ“œ SIMILAR VOLUMES

Purine mutants of mammalian cell lines.
Purine mutants of mammalian cell lines. II. Identification of a phosphoribosylpyrophosphate amidotransferase-deficient mutant of Chinese hamster lung cells
โœ Rhoda I. Feldman; Milton W. Taylor ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Springer ๐ŸŒ English โš– 365 KB

A class of purine auxotrophs blocked early in the purine biosynthetic pathway was examined. The inability of these mutants to accumulate formylglycinamide ribotide (FGAR) in the presence of azaserine suggested that one or more of the first three enzymes of the pathway were either missing or defectiv