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Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: Characterization of Chinese hamster cell mutants defective in phosphoribosylpyrophosphate amidotransferase and phosphoribosylglycinamide synthetase and an examination of alternatives to the first step of purine biosynthesis

✍ Scribed by Dale C. Oates; David Patterson


Book ID
112558880
Publisher
Springer
Year
1977
Tongue
English
Weight
851 KB
Volume
3
Category
Article
ISSN
1572-9931

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Biochemical genetic analysis of pyrimidi
✍ Thomas D. Stamato; David Patterson πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 798 KB

## Abstract A mutant (A204) of Chinese hamster ovary cells (CHO‐K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3.3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact ce