Purification of monoclonal antibodies by continuous chromatography (MCSGP)
β Scribed by M. Morbidelli
- Publisher
- Elsevier
- Year
- 2009
- Tongue
- English
- Weight
- 72 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1871-6784
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Multicolumn countercurrent solvent gradient purification (MCSGP) is a continuous chromatographic process developed in recent years (Aumann and Morbidelli, 2007a; Aumann et al., 2007) that is particularly suited for applications in the field of bioseparations. Like batch chromatography,
## Abstract The large scale production of monoclonal antibodies presents a challenge to design efficient and cost effective downstream purification processes. We explored a two stage resin screening approach to identify the best candidates to be utilized for the platform purification of monoclonal
## Abstract Weak partitioning chromatography (WPC) is an isocratic chromatographic protein separation method performed under mobile phase conditions where a significant amount of the product protein binds to the resin, well in excess of typical flowthrough operations. The more stringent load and wa
## Abstract Monoclonal antibody was purified from tissue culture fluid using ceramic fluoroapatite chromatography. Efficiency of the capture step was shown to be sensitive to pH and phosphate concentration. More than 90% of host cell proteins were removed by ceramic fluoroapatite chromatography. St