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Pulpal lesions in normal and cyclosporin A treated rats

✍ Scribed by Márcio Ajudarte Lopes; Luís Carlos Spolidório; Sérgio Roberto Peres Line; Oslei Paes de Almeida

Book ID
117274461
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
180 KB
Volume
23
Category
Article
ISSN
0099-2399

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✍ U. Helmchen; W. E. Schmidt; E. G. Siegel; W. Creutzfeldt 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 695 KB

Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.