Immunolocalization of cyclophilin in normal and cyclosporin A-treated human lymphocytes
✍ Scribed by Věra Hašková; Ladislava Rozprimová; Jiří Hašek; Markéta Jelínková
- Book ID
- 107908526
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 728 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0165-2478
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Human cyclophilin A (hCypA) contains one tryptophan residue at position 121 (Trp121). The fluorescence intensity of this single tryptophan residue doubles upon binding the clinically important immunosuppressant cyclosporin A (CsA). Trp121 is in close contact to the bound CsA and is well-conserved in