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Immunolocalization of prealbumin: Distribution in normal human tissue

✍ Scribed by Christine N. Liddle; W. A. Reid; J. S. Kennedy; I. D. Miller; Professor C. H. W. Horne

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 768 KB
Volume: 146
Category: Article
ISSN: 0022-3417
DOI: 10.1002/path.1711460205

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Using an indirect immunoperoxidase staining technique we have demonstrated the plasma protein, prealbumin, in the cells of the pancreatic islets of Langerhans. Serial sections stained with antisera to glucagon, insulin and somatostatin revealed that the distribution of the prealbumin stained cells matched that of the glucagon A‐cells. Absorption and cross‐absorption experiments with prealbumin and glucagon showed that the staining was specific. We also found positive staining for prealbumin in single cells in the mucosa of the gastrointestinal tract, mainly stomach and colon, and kidney tubules.

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