Mutations of CEBPA in acute myeloid leuk
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Jennifer Snaddon; Matthew L. Smith; Michael Neat; Maxine Cambal-Parrales; Amanda
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Article
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2003
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John Wiley and Sons
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English
⚖ 445 KB
CEBPA encodes the transcription factor C/EBPalpha and is specifically up-regulated during granulocytic differentiation. The gene is mutated in approximately 20% of patients with acute myeloid leukemia (AML) FAB type M2 and occurs in the absence of the t(8;21). In much the same way as specific transl