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PTEN/MMAC1Mutations in Hepatocellular Carcinomas: Somatic Inactivation of Both Alleles in Tumors

✍ Scribed by Kawamura, Naoki ;Nagai, Hisaki ;Bando, Koichi ;Koyama, Masaaki ;Matsumoto, Satoshi ;Tajiri, Takashi ;Onda, Masahiko ;Fujimoto, Jiro ;Ueki, Takahiro ;Konishi, Noboru ;Shiba, Tadayoshi ;Emi, Mitsuru

Book ID
108581745
Publisher
Wiley (Blackwell Publishing)
Year
1999
Tongue
English
Weight
184 KB
Volume
90
Category
Article
ISSN
0910-5050

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## Abstract ## BACKGROUND Inactivation of the tumor suppressor gene __PTEN__/__MMAC1__/__TEP1__, located on chromosome 10q23, is a common event in advanced stages of diverse human malignancies. However, the prognostic role of __PTEN__ expression in patients with hepatocellular carcinoma (HCC) has