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PTEN/MMAC1 mutations in hepatocellular carcinomas

✍ Scribed by Yao, Ya Juan; Ping, Xiao Li; Zhang, Hong; Chen, Fei Fei; Lee, Patricia K; Ahsan, Habibul; Chen, Chien-Jen; Lee, Po-Huang; Peacocke, Monica; Santella, Regina M


Book ID
110062093
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
120 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract ## BACKGROUND Inactivation of the tumor suppressor gene __PTEN__/__MMAC1__/__TEP1__, located on chromosome 10q23, is a common event in advanced stages of diverse human malignancies. However, the prognostic role of __PTEN__ expression in patients with hepatocellular carcinoma (HCC) has

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Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid dual-specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been identified in a number of cancer c