PTEN/MMAC1 mutations in hepatocellular carcinomas
β Scribed by Yao, Ya Juan; Ping, Xiao Li; Zhang, Hong; Chen, Fei Fei; Lee, Patricia K; Ahsan, Habibul; Chen, Chien-Jen; Lee, Po-Huang; Peacocke, Monica; Santella, Regina M
- Book ID
- 110062093
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 120 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## Abstract ## BACKGROUND Inactivation of the tumor suppressor gene __PTEN__/__MMAC1__/__TEP1__, located on chromosome 10q23, is a common event in advanced stages of diverse human malignancies. However, the prognostic role of __PTEN__ expression in patients with hepatocellular carcinoma (HCC) has
Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid dual-specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been identified in a number of cancer c