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Psoralen/UVA treatment and chromosomes

✍ Scribed by Anton Brøgger; Helga Waksvik; Per Thune

Book ID
104780053
Publisher
Springer-Verlag
Year
1978
Tongue
English
Weight
450 KB
Volume
261
Category
Article
ISSN
0340-3696

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✦ Synopsis

Five psoriasis patients treated with 8-methoxypsoralen and UVA (PUVA) were studied by lymphocyte cultures at the 1st, 5th, 10th and 20th treatment and at a maintenance treatment 6 months later. Abnormal amounts of chromosome aberrations were not found, and the frequency of sister chromatid exchange (examined at the last treatment) was not increased. In vitro experiments with nanogram doses of psoralen (similar to plasma levels in patients) showed no increase in chromosome aberration or SCE freqency. The results indicate that therapeutic doses of PUVA have no clastogenic effect.

📜 SIMILAR VOLUMES

Psoralen/UVA treatment and chromosomes
Psoralen/UVA treatment and chromosomes
✍ Helga Waksvik; Anton Brøgger; Jon Stene 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 686 KB

Treatment of human lymphocytes in vitro with trimethylpsoralen or 8-methoxypsoralen and UVA irradiation (PUVA) induced chromosome damage, mainly constrictions and gaps, but also breaks and exchanges, and increased the frequency of sister chromatid exchange (SCE). The localization of the chromosome a