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Granuloma faciale: Treatment with topical psoralen and UVA

✍ Scribed by Hudson, Larry D.


Book ID
123187564
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
739 KB
Volume
8
Category
Article
ISSN
1097-6787

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Treatment of human lymphocytes in vitro with trimethylpsoralen or 8-methoxypsoralen and UVA irradiation (PUVA) induced chromosome damage, mainly constrictions and gaps, but also breaks and exchanges, and increased the frequency of sister chromatid exchange (SCE). The localization of the chromosome a

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Five psoriasis patients treated with 8-methoxypsoralen and UVA (PUVA) were studied by lymphocyte cultures at the 1st, 5th, 10th and 20th treatment and at a maintenance treatment 6 months later. Abnormal amounts of chromosome aberrations were not found, and the frequency of sister chromatid exchange