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Pseudodipeptide Inhibitors of Protein Farnesyltransferase

โœ Scribed by deSolms, S. Jane; Deana, Albert A.; Giuliani, Elizabeth A.; Graham, Samuel L.; Kohl, Nancy E.; Mosser, Scott D.; Oliff, Allen I.; Pompliano, David L.; Rands, Elaine

Book ID
126290896
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
641 KB
Volume
38
Category
Article
ISSN
0022-2623

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A variety of compounds that show promise in cancer chemotherapy and chemoprevention have been identified as farnesyltransferase inhibitors. These can be classified into mainly two different types of inhibitors, farnesyl diphosphate competitors and CAAX peptidomimetics. The former type acts by compet