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Protein farnesyltransferase inhibitors and progeria

✍ Scribed by Margarita Meta; Shao H. Yang; Martin O. Bergo; Loren G. Fong; Stephen G. Young

Book ID
116758050
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
503 KB
Volume
12
Category
Article
ISSN
1471-4914

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A variety of compounds that show promise in cancer chemotherapy and chemoprevention have been identified as farnesyltransferase inhibitors. These can be classified into mainly two different types of inhibitors, farnesyl diphosphate competitors and CAAX peptidomimetics. The former type acts by compet