Pseudo-symmetrical difluoroketones: Highly potent and specific inhibitors of HIV-1 protease
β Scribed by Hing L. Sham; David A. Betebenner; Norman Wideburg; Ayda C. Saldivar; William E. Kohlbrenner; Adrienne Craig-Kennard; Sudthida Vasavanonda; Dale J. Kempf; Jacob J. Clement; John E. Erickson; Jacob J. Plattner; Daniel W. Norbeck
- Book ID
- 115927400
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 380 KB
- Volume
- 329
- Category
- Article
- ISSN
- 0014-5793
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π SIMILAR VOLUMES
Scheme 1. General synthesis of target compounds 5. A) hn, l > 270 nm, THF, 6 weeks, 25 8C; B) LiAlH 4 (2 equiv), THF, 24 h, Γ8 8C.
With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After