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Rational design of irreversible, pseudo-C2-symmetric hiv-1 protease inhibitors

✍ Scribed by Chihyo Park; Jong Sung Koh; Young Chan Son; Ho-il Choi; Chang Sun Lee; Nakyen Choy; Kwang Yul Moon; Won Hee Jung; Sung Chun Kim; Heungsik Yoon


Book ID
108038875
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
325 KB
Volume
5
Category
Article
ISSN
0960-894X

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Facile Syntheses of C2-Symmetrical HIV-1
✍ Stephan KΓΆnig; Ivar Ugi; Hans J. Schramm πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 583 KB

With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After