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Structure-based, C2 symmetric inhibitors of HIV protease

✍ Scribed by Kempf, Dale J.; Norbeck, Daniel W.; Codacovi, LynnMarie; Wang, Xiu Chun; Kohlbrenner, William E.; Wideburg, Norman E.; Paul, Deborah A.; Knigge, Mark F.; Vasavanonda, Sudthida


Book ID
126901574
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
398 KB
Volume
33
Category
Article
ISSN
0022-2623

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Facile Syntheses of C2-Symmetrical HIV-1
✍ Stephan KΓΆnig; Ivar Ugi; Hans J. Schramm πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 583 KB

With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After