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Novel Insight into Inhibitor Binding of Highly Symmetric HIV-1 Protease

✍ Scribed by Jörg Wollmann; Christiane Baumert; German Erlenkamp; Wolfgang Sippl; Andreas Hilgeroth

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
392 KB
Volume
9
Category
Article
ISSN
1439-4227

No coin nor oath required. For personal study only.

✦ Synopsis

Scheme 1. General synthesis of target compounds 5. A) hn, l > 270 nm, THF, 6 weeks, 25 8C; B) LiAlH 4 (2 equiv), THF, 24 h, À8 8C.

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Facile Syntheses of C2-Symmetrical HIV-1
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✍ Stephan König; Ivar Ugi; Hans J. Schramm 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 583 KB

With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After