SDZ PSC 833, A non-immunosuppressive cyc
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Roland P. Keller; Hans J. Altermatt; Kees Nooter; Guenter Poschmann; Jean A. Lai
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Article
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1992
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John Wiley and Sons
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French
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Cyclosporin A (CsA, Sandimmune) is known to reverse P-glycoprotein(P-gp I70)mediated multidrug resistance as efficiently as other prototype compounds of resistance modifiers. The immunosuppressive activity and nephrotoxicity of CsA, however, may limit its clinical use. PSC-833, a new cyclosporine, e