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SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein

โœ Scribed by Celia W Goulding; Armando E Giuliano; Myles C Cabot


Book ID
117469707
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
296 KB
Volume
149
Category
Article
ISSN
0304-3835

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SDZ PSC833 (PSC833). an analogue of cyclosporines, is one of the most potent modulators of multi-drug resistance (MDR). We previously reported that MRK-16, an anti-P-glycoprotein MAC. enhanced MDR reversal activity of cyclosporin A (CsA) through inhibition of P-glycoprotein-mediated CrA transport. W