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Protracted treatment with tegafur and low dose oral leucovorin in patients with advanced colorectal carcinoma

✍ Scribed by Miquel Nogué; Miquel A. Seguí; Eugeni Saigí; Eduard Batiste-Alentorn; Angels Arcusa; Montserrat Boleda; Isabel Antón

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
64 KB
Volume
83
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Protracted oral administration of tegafur (TG) and leucovorin (LV) attempts to simulate the continuous infusion of 5-fluorouracil, with a higher intracellular folate pool. In a prior dose-finding study with a fixed TG dose of 0.75 g/m 2 /day for a period of 21 days and continuous oral LV, the recommended dose of LV was 45 mg/day in 28-day cycles.

METHODS.

Thirty-nine patients with histologic confirmation of adenocarcinoma of the colon or rectum, either advanced or metastatic disease, and who were not candidates for radical treatment were included in a Phase II study using this schedule.

📜 SIMILAR VOLUMES

Hypocalcemia associated with 5-fluoroura
Hypocalcemia associated with 5-fluorouracil and low dose leucovorin in patients with advanced colorectal or gastric carcinomas
✍ Yuichiro Kido; Takeshi Okamura; Morimasa Tomikawa; Manabu Yamamoto; Morio Shirai 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 367 KB 👁 2 views

## BACKGROUND. The biochemical modulation of 5-fluorouracil (5-FU) by leucovorin (Lv) has demonstrated significantly increased response rates in comparison with the use of 5-FU alone in patients with advanced colorectal carcinoma. However, the higher response rate of LV/5-FU may occur at the expen