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Protonation of the Binuclear Metal Center within the Active Site of Phosphotriesterase †

✍ Scribed by Samples, Cynthia R.; Howard, Timothy; Raushel, Frank M.; DeRose, Victoria J.


Book ID
126848805
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
160 KB
Volume
44
Category
Article
ISSN
0006-2960

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✍ Linette M. Watkins; Jane M. Kuo; Misty Chen-Goodspeed; Frank M. Raushel 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 1 views

Phosphotriesterase (PTE) is a zinc metalloenzyme that catalyzes the hydrolysis of an extensive array of organophosphate pesticides and mammalian acetylcholinesterase nerve agents. Although the three-dimensional crystal structure of PTE has been solved (M. M. Benning et al., Biochemistry 34:7973-7978