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Protonation-Assisted Conjugate Addition of Axially Chiral Enolates: Asymmetric Synthesis of Multisubstituted β-Lactams from α-Amino Acids

✍ Scribed by Yoshimura, Tomoyuki; Takuwa, Masatoshi; Tomohara, Keisuke; Uyama, Makoto; Hayashi, Kazuhiro; Yang, Pan; Hyakutake, Ryuichi; Sasamori, Takahiro; Tokitoh, Norihiro; Kawabata, Takeo


Book ID
118754136
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
538 KB
Volume
18
Category
Article
ISSN
0947-6539

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Asymmetric synthesis of β-amino acids an
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Asymmetric conjugate addition / a,P-Unsaturated esters / Homochiral amidocuprates / P-Amino acids / a-Deuterio p-amino acids Conjugate addition of homochiral amidocuprates based on N-[(R)-1-phenylethyl]trimethylsilylamine or bis[(R)-1-phenylethyllamine to a,p-unsaturated esters provides an efficient