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Organocatalytic Conjugate Addition of Malonates to α,β-Unsaturated Aldehydes: Asymmetric Formal Synthesis of (-)-Paroxetine, Chiral Lactams, and Lactones.

✍ Scribed by Sven Brandau; Aitor Landa; Johan Franzen; Mauro Marigo; Karl Anker Joergensen

Publisher
John Wiley and Sons
Year
2006
Weight
39 KB
Volume
37
Category
Article
ISSN
0931-7597

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Organocatalytic Conjugate Addition of Ma
Organocatalytic Conjugate Addition of Malonates to α,β-Unsaturated Aldehydes: Asymmetric Formal Synthesis of (−)-Paroxetine, Chiral Lactams, and Lactones
✍ Sven Brandau; Aitor Landa; Johan Franzén; Mauro Marigo; Karl Anker Jørgensen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 1 views

Chiral lactones and lactams are endowed with a large spectrum of biological properties [1] including very important pharmaceutical activities. [2] The chiral piperidines (À)paroxetine hydrochloride 1, marketed as paxil/seroxat, and (+)-femoxetine 2 are selective serotonin reuptake inhibitors and are