𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Proton NMR observation of glycogen in vivo

✍ Scribed by Wei Chen; Malcolm J. Avison; Gilles Bloch; Robert G. Shulman

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
418 KB
Volume
31
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Our previous solution studies of the proton relaxation properties of glycogen H1 have shown significant dipolar cross–relaxation with intra‐ring H2 and inter‐ring H4β€² protons characterized by a correlation time Ο„~c~= 2.7 Γ— 10^βˆ’9^ s. This leads to a significant negative Nuclear Overhauser Enhancement (NOE) of glycogen H1 following either transient or steady state perturbations of the longitudinal magnetization of dipolar coupled protons, especially H2 and H4β€². Here we use the NOE to edit selectively the H1 resonance of glycogen in the rat liver in vivo using a surface coil probe. The approach shows the possibility of measuring glycogen in vivo with high sensitivity using ^1^H NMR.

πŸ“œ SIMILAR VOLUMES

13 C NMR visibility of rabbit muscle gly
13 C NMR visibility of rabbit muscle glycogen in vivo
✍ Rolf Gruetter; Tomas A. Prolla; Robert G. Shulman πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 368 KB

## Abstract The integrated ^13^C NMR intensity of the glycogen Cl resonance was measured in skeletal muscle (biceps femoris region) of nine rabbits under __in vivo__ conditions. Concurrent chemical determinations of glycogen content showed that the __in vivo__ signal was 1.02 Β± 0.06 the intensity o

Visibility of mammalian hepatic glycogen
Visibility of mammalian hepatic glycogen to the NMR experiment, in vivo
✍ Robert A. Shalwitz; Nicholas V. Reo; Nancy N. Becker; Joseph J. H. Ackerman πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 277 KB

An in vivo 13C NMR study was performed to investigate whether the relaxation properties of the C-1 carbon of the glucopyranose residues of glycogen changed as the molecule increased in size. There was no change in resonance intensity or linewidth. Therefore, no significant change in T1 or T2 was obs

Proton NMR Observation of the Antineopla
Proton NMR Observation of the Antineoplastic Agent Iproplatin In Vivo by Selective Multiple Quantum Coherence Transfer (Sel-MQC)
✍ Qiuhong He; Zaver M. Bhujwalla; Ross J. Maxwell; John R. Griffiths; Jerry D. Gli πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 283 KB

## Abstract We have noninvasively detected the proton signal of an antineoplastic agent Iproplatin __in vivo__ by selective multiple quantum coherence transfer (Sel‐MQC). Without isotopic labeling or chemical modification, the Sel‐MQC method labels Iproplatin by its intrinsic proton multiple quantu

Quantification of glutamate, glutamine,
Quantification of glutamate, glutamine, and other metabolites in In Vivo proton NMR spectroscopy
✍ W. M. M. J. BovΓ©e πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 403 KB

## Abstract A reliable quantification of __in vivo__ ^1^H MRS spectra is hampered by extensive line overlap, by intensity distortions due to the water suppressing pulse sequence and complex modulation patterns of __J__‐coupled spins, and by deviations between the experimental and model lineshapes i