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Proton NMR Observation of the Antineoplastic Agent Iproplatin In Vivo by Selective Multiple Quantum Coherence Transfer (Sel-MQC)

✍ Scribed by Qiuhong He; Zaver M. Bhujwalla; Ross J. Maxwell; John R. Griffiths; Jerry D. Glickson

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 283 KB
Volume: 33
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910330315

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We have noninvasively detected the proton signal of an antineoplastic agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel‐MQC). Without isotopic labeling or chemical modification, the Sel‐MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.

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