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In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer

✍ Scribed by Manickam Muruganandham; Jason A. Koutcher; Giuseppe Pizzorno; Qiuhong He

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 294 KB
Volume: 52
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.20206

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✦ Synopsis

Abstract

The frequency‐selective multiple‐quantum‐coherence (Sel‐MQC) lactate (Lac) filter offers complete lipid and water suppression in a single scan for robust in vivo detection of tumor Lac, even in the presence of abundant lipids. Conversion of the detected signal into accurate tissue concentrations of Lac requires knowledge of in vivo Lac T~1~ and T~2~ relaxation times. This work reports modifications to the Sel‐MQC pulse sequence, T~1~‐ and T~2~‐Sel‐MQC, that facilitate relaxation measurements of Lac. The T~1~‐Sel‐MQC sequence combines an inversion prepulse with the Sel‐MQC filter. The T~2~‐Sel‐MQC sequence incorporates a CH~3~‐selective 180° pulse during the MQ preparation period to overcome the J‐modulation effects and allow the insertion of variable echo delays. The performance of these sequences was evaluated with the use of phantoms and subcutaneous murine tumor models in vivo. The present approach will allow investigators to correct for the relaxation‐induced Lac signal loss in Sel‐MQC experiments for the quantitative mapping of in vivo tumor Lac distribution. Magn Reson Med 52:902–906, 2004. © 2004 Wiley‐Liss, Inc.

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