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Proton magnetic resonance studies of compounds with bridgehead nitrogen. Part 39. Stereochemistry of perhydropyrido[3,2,1-ij][3,1]benzoxazines and the conformational equilibrium for perhydropyrido[1,2-c][1,3]oxazine

✍ Scribed by Crabb, Trevor A.; Turner, Christopher H.


Book ID
120195016
Publisher
Royal Society of Chemistry
Year
1980
Tongue
English
Weight
581 KB
Volume
12
Category
Article
ISSN
1472-779X

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Compounds with bridgehead nitrogen. 57—N
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Protonation of perhydrooxazolo[3,4-a~pyridine, perhydropyrido[1,2-~~[1,3]oxazine and perhydropyridoI 1,2c][ 1,310xazepine by hydrogen chloride gas in diethyl ether gave mixtures of trans-and cis-fused hydrochlorides containing 28, 75 and 79% of the trans-fused salts, respectively, which compare with

Compounds with bridgehead nitrogen 68—NM
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## Abstract Low‐temperature ^13^C NMR spectroscopy shows perhydropyrido [1,2‐__c__] [1,3]oxazine to adopt a conformational equilibrium in CD~2~Cl~2~–CFCl~3~ solution containing 98% __trans__ fused conformer in equilibrium with 2% __O__‐outside‐__cis__ fused conformer at 203 K. A similar equilibrium

Compounds with bridgehead nitrogen. 44—t
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## Abstract The 270 MHz NMR data on __trans__‐ and __cis__‐(H‐4a, H‐7)‐7‐ethylperhydropyrido[1,2‐__c__][1,3]thiazine show heavy conformational bias to the __trans__‐ and __S__‐inside __cis__‐fused conformations, respectively. Comparison of the ^13^C NMR spectra of these anancomeric systems with the

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✍ Trevor A. Crabb; Graham C. Jackson 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 745 KB

## Abstract A series of perhydropyrido[1,2‐__c__][1,6,3]dioxazocines and 2‐alkylperhydropyrido[1,2‐__c__][1,3,6]oxdiazocines have been prepared. 6‐__p__‐Nitrophenyl‐3,4‐dimethylperhydropyrido[1,2‐__c__][1,6,3]‐dioxazodioxazocine is shown to adopt the __cis__ fused ring conformation in solution with

Compounds with bridgehead nitrogen. 63—N
✍ Trevor A. Crabb; Asadollah Fallah 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 417 KB

## Abstract The configurations and conformations of diastereoisomeric 1‐(decahydroquinolin‐8‐yl)butan‐2‐ols and of perhydropyrido[3,2,1‐__j,k__][3,1]benzoxazepines resulting from ring closure of these compounds with formaldehyde have been assigned by ^1^H and ^13^C NMR spectroscopy.