## Abstract Low‐temperature ^13^C NMR spectroscopy shows perhydropyrido [1,2‐__c__] [1,3]oxazine to adopt a conformational equilibrium in CD~2~Cl~2~–CFCl~3~ solution containing 98% __trans__ fused conformer in equilibrium with 2% __O__‐outside‐__cis__ fused conformer at 203 K. A similar equilibrium
Compounds with bridgehead nitrogen. 63—NMR spectra and stereochemistry of perhydropyrido[3,2,1-j,k][3,1]benzoxazepines
✍ Scribed by Trevor A. Crabb; Asadollah Fallah
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 417 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0749-1581
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The configurations and conformations of diastereoisomeric 1‐(decahydroquinolin‐8‐yl)butan‐2‐ols and of perhydropyrido[3,2,1‐j,k][3,1]benzoxazepines resulting from ring closure of these compounds with formaldehyde have been assigned by ^1^H and ^13^C NMR spectroscopy.
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## Abstract Six of the eight possible diastereoisomeric 5‐methylperhydropyrido[3,2,1‐__i__,__j__][3,1]benzoxazines have been synthesized, and the utility of the C‐3 methylene proton NMR parameters [__J__(3ax3eq) and Δ3ax3eq] in the assignment of configurations has been demonstrated.
## Abstract The 270 MHz NMR data on __trans__‐ and __cis__‐(H‐4a, H‐7)‐7‐ethylperhydropyrido[1,2‐__c__][1,3]thiazine show heavy conformational bias to the __trans__‐ and __S__‐inside __cis__‐fused conformations, respectively. Comparison of the ^13^C NMR spectra of these anancomeric systems with the
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The configurations and preferred conformations of some diastereoisomeric perhydronaphthaleno[2,1-elpyrido[ 1,2c][ 1,310xazines have been assigned by "C NMR spectroscopy. These results require reversal of two previous tentative configurational assignments based on 'H NMR spectroscopy, and also indica
## Abstract Seven of the possible diastereoisomeric perhydronaphthaleno[3,4‐__e__]pyrido[1,2‐__c__][1,3]oxazines have been synthesized and the configurations and preferred conformations of these assigned on the basis of IR and ^1^H NMR spectroscopy and the application of conformational principles.