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Proton and carbon chemical shift assignment and dynamic investigation of the macrolide antibiotic tylosin

✍ Scribed by Claudio Rossi; Alessandro Donati; Maria Pia Picchi; Maria Rosaria Sansoni; Gianfranco Corbini; Piero Corti

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 271 KB
Volume: 30
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260301007

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The NMR spectral properties of the antibiotic tylosin were investigated. DQ‐COSY and HETCOR two‐dimensional spectra were used for the assignment of both the proton and protonated carbon signals. Selective (H)C‐NOE, were proposed for the controversial quaternary carbon assignments. The analysis of molecular motion in solution based on carbon spin–lattice relaxation rates shows that tylosin exhibits dynamics that are typical of each molecular moiety. A higher degree of free motion is observed with increasing distance from the macrolide nucleus.

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